Use of zebrafish to study Shigella infection

Use of zebrafish to study Shigella infection

Blog Article

Shigella is a leading cause of dysentery worldwide, responsible for up to 165 million cases of shigellosis each year.Shigella is also recognised as an exceptional model pathogen to study key issues in cell biology and innate immunity.Several infection models have been useful to explore Shigella biology; however, we still lack information regarding the events taking place canon imageclass mf227dw during the Shigella infection process in vivo.Here, we discuss a selection of mechanistic insights recently gained from studying Shigella infection of zebrafish (Danio rerio), with a focus on cytoskeleton rearrangements and cellular immunity.We also discuss how infection of zebrafish can be used to investigate new concepts underlying infection control, including emergency granulopoiesis and the use of predatory bacteria to combat antimicrobial resistance.

Collectively, these insights illustrate how Shigella infection of zebrafish redken shades 9gi can provide fundamental advances in our understanding of bacterial pathogenesis and vertebrate host defence.This information should also provide vital clues for the discovery of new therapeutic strategies against infectious disease in humans.